Natural Product Mediated Regulation of Death Receptors and Intracellular Machinery: Fresh from the Pipeline about TRAIL-Mediated Signaling and Natural TRAIL Sensitizers
Identifieur interne : 000599 ( Main/Exploration ); précédent : 000598; suivant : 000600Natural Product Mediated Regulation of Death Receptors and Intracellular Machinery: Fresh from the Pipeline about TRAIL-Mediated Signaling and Natural TRAIL Sensitizers
Auteurs : Durray Shahwar ; Muhammad Javed Iqbal [Pakistan] ; Mehr-Un Nisa ; Milica Todorovska ; Rukset Attar ; Uteuliyev Yerzhan Sabitaliyevich ; Ammad Ahmad Farooqi ; Aamir Ahmad ; Baojun Xu [République populaire de Chine]Source :
- International Journal of Molecular Sciences [ 1422-0067 ] ; 2019.
Abstract
Rapidly developing resistance against different therapeutics is a major stumbling block in the standardization of therapy. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated signaling has emerged as one of the most highly and extensively studied signal transduction cascade that induces apoptosis in cancer cells. Rapidly emerging cutting-edge research has helped us to develop a better understanding of the signaling machinery involved in inducing apoptotic cell death. However, excitingly, cancer cells develop resistance against TRAIL-induced apoptosis through different modes. Loss of cell surface expression of TRAIL receptors and imbalance of stoichiometric ratios of pro- and anti-apoptotic proteins play instrumental roles in rewiring the machinery of cancer cells to develop resistance against TRAIL-based therapeutics. Natural products have shown excellent potential to restore apoptosis in TRAIL-resistant cancer cell lines and in mice xenografted with TRAIL-resistant cancer cells. Significantly refined information has previously been added and continues to enrich the existing pool of knowledge related to the natural-product-mediated upregulation of death receptors, rebalancing of pro- and anti-apoptotic proteins in different cancers. In this mini review, we will set spotlight on the most recently published high-impact research related to underlying mechanisms of TRAIL resistance and how these deregulations can be targeted by natural products to restore TRAIL-mediated apoptosis in different cancers.
Url:
DOI: 10.3390/ijms20082010
PubMed: 31022877
PubMed Central: 6515249
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Natural Product Mediated Regulation of Death Receptors and Intracellular Machinery: Fresh from the Pipeline about TRAIL-Mediated Signaling and Natural TRAIL Sensitizers</title><author><name sortKey="Shahwar, Durray" sort="Shahwar, Durray" uniqKey="Shahwar D" first="Durray" last="Shahwar">Durray Shahwar</name><affiliation><nlm:aff id="af1-ijms-20-02010">Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore 54840, Pakistan;<email>durrayshahwar.kh@gmail.com</email> (D.S.);<email>ammadfarooqi@rlmclahore.com</email> (A.A.F.)</nlm:aff></affiliation></author><author><name sortKey="Iqbal, Muhammad Javed" sort="Iqbal, Muhammad Javed" uniqKey="Iqbal M" first="Muhammad Javed" last="Iqbal">Muhammad Javed Iqbal</name><affiliation><nlm:aff id="af2-ijms-20-02010">Department of Biochemistry and Biotechnology, University of Gujrat, Gujrat 34120, Pakistan;<email>m.javediqbal@uog.edu.pk</email></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ijms-20-02010">Department of Biotechnology, University of Sialkot, Sialkot 51310, Pakistan</nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Biotechnology, University of Sialkot, Sialkot 51310</wicri:regionArea><wicri:noRegion>Sialkot 51310</wicri:noRegion></affiliation></author><author><name sortKey="Nisa, Mehr Un" sort="Nisa, Mehr Un" uniqKey="Nisa M" first="Mehr-Un" last="Nisa">Mehr-Un Nisa</name><affiliation><nlm:aff id="af4-ijms-20-02010">National Institute of Food Science and Technology, UAF, Faisalabad 38000, Pakistan;<email>mehru912@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Todorovska, Milica" sort="Todorovska, Milica" uniqKey="Todorovska M" first="Milica" last="Todorovska">Milica Todorovska</name><affiliation><nlm:aff id="af5-ijms-20-02010">Department of Pharmacy, Medical Faculty, University of Niš, Dr Zorana Djindjica Boulevard 81, 18000 Niš, Serbia;<email>mimatod@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Attar, Rukset" sort="Attar, Rukset" uniqKey="Attar R" first="Rukset" last="Attar">Rukset Attar</name><affiliation><nlm:aff id="af6-ijms-20-02010">Department of Obstetrics and Gynecology, Yeditepe University, Ataşehir/İstanbul 34755, Turkey;<email>ruksetattar@hotmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Sabitaliyevich, Uteuliyev Yerzhan" sort="Sabitaliyevich, Uteuliyev Yerzhan" uniqKey="Sabitaliyevich U" first="Uteuliyev Yerzhan" last="Sabitaliyevich">Uteuliyev Yerzhan Sabitaliyevich</name><affiliation><nlm:aff id="af7-ijms-20-02010">Kazakhstan Medical University “KSPH”, Almaty 050060, Kazakhstan;<email>e.uteuliyev@ksph.kz</email></nlm:aff></affiliation></author><author><name sortKey="Farooqi, Ammad Ahmad" sort="Farooqi, Ammad Ahmad" uniqKey="Farooqi A" first="Ammad Ahmad" last="Farooqi">Ammad Ahmad Farooqi</name><affiliation><nlm:aff id="af1-ijms-20-02010">Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore 54840, Pakistan;<email>durrayshahwar.kh@gmail.com</email> (D.S.);<email>ammadfarooqi@rlmclahore.com</email> (A.A.F.)</nlm:aff></affiliation></author><author><name sortKey="Ahmad, Aamir" sort="Ahmad, Aamir" uniqKey="Ahmad A" first="Aamir" last="Ahmad">Aamir Ahmad</name><affiliation><nlm:aff id="af8-ijms-20-02010">Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA;<email>aahmad@health.southalabama.edu</email></nlm:aff></affiliation></author><author><name sortKey="Xu, Baojun" sort="Xu, Baojun" uniqKey="Xu B" first="Baojun" last="Xu">Baojun Xu</name><affiliation wicri:level="1"><nlm:aff id="af9-ijms-20-02010">Food Science and Technology Program, Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai 519087, Guangdong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Food Science and Technology Program, Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai 519087, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31022877</idno><idno type="pmc">6515249</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515249</idno><idno type="RBID">PMC:6515249</idno><idno type="doi">10.3390/ijms20082010</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000A09</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A09</idno><idno type="wicri:Area/Pmc/Curation">000A09</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A09</idno><idno type="wicri:Area/Pmc/Checkpoint">000550</idno><idno type="wicri:explorRef" 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(D.S.);<email>ammadfarooqi@rlmclahore.com</email> (A.A.F.)</nlm:aff></affiliation></author><author><name sortKey="Iqbal, Muhammad Javed" sort="Iqbal, Muhammad Javed" uniqKey="Iqbal M" first="Muhammad Javed" last="Iqbal">Muhammad Javed Iqbal</name><affiliation><nlm:aff id="af2-ijms-20-02010">Department of Biochemistry and Biotechnology, University of Gujrat, Gujrat 34120, Pakistan;<email>m.javediqbal@uog.edu.pk</email></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ijms-20-02010">Department of Biotechnology, University of Sialkot, Sialkot 51310, Pakistan</nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Biotechnology, University of Sialkot, Sialkot 51310</wicri:regionArea><wicri:noRegion>Sialkot 51310</wicri:noRegion></affiliation></author><author><name sortKey="Nisa, Mehr Un" sort="Nisa, Mehr Un" uniqKey="Nisa M" first="Mehr-Un" last="Nisa">Mehr-Un Nisa</name><affiliation><nlm:aff id="af4-ijms-20-02010">National Institute of Food Science and Technology, UAF, Faisalabad 38000, Pakistan;<email>mehru912@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Todorovska, Milica" sort="Todorovska, Milica" uniqKey="Todorovska M" first="Milica" last="Todorovska">Milica Todorovska</name><affiliation><nlm:aff id="af5-ijms-20-02010">Department of Pharmacy, Medical Faculty, University of Niš, Dr Zorana Djindjica Boulevard 81, 18000 Niš, Serbia;<email>mimatod@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Attar, Rukset" sort="Attar, Rukset" uniqKey="Attar R" first="Rukset" last="Attar">Rukset Attar</name><affiliation><nlm:aff id="af6-ijms-20-02010">Department of Obstetrics and Gynecology, Yeditepe University, Ataşehir/İstanbul 34755, Turkey;<email>ruksetattar@hotmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Sabitaliyevich, Uteuliyev Yerzhan" sort="Sabitaliyevich, Uteuliyev Yerzhan" uniqKey="Sabitaliyevich U" first="Uteuliyev Yerzhan" last="Sabitaliyevich">Uteuliyev Yerzhan Sabitaliyevich</name><affiliation><nlm:aff id="af7-ijms-20-02010">Kazakhstan Medical University “KSPH”, Almaty 050060, Kazakhstan;<email>e.uteuliyev@ksph.kz</email></nlm:aff></affiliation></author><author><name sortKey="Farooqi, Ammad Ahmad" sort="Farooqi, Ammad Ahmad" uniqKey="Farooqi A" first="Ammad Ahmad" last="Farooqi">Ammad Ahmad Farooqi</name><affiliation><nlm:aff id="af1-ijms-20-02010">Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore 54840, Pakistan;<email>durrayshahwar.kh@gmail.com</email> (D.S.);<email>ammadfarooqi@rlmclahore.com</email> (A.A.F.)</nlm:aff></affiliation></author><author><name sortKey="Ahmad, Aamir" sort="Ahmad, Aamir" uniqKey="Ahmad A" first="Aamir" last="Ahmad">Aamir Ahmad</name><affiliation><nlm:aff id="af8-ijms-20-02010">Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA;<email>aahmad@health.southalabama.edu</email></nlm:aff></affiliation></author><author><name sortKey="Xu, Baojun" sort="Xu, Baojun" uniqKey="Xu B" first="Baojun" last="Xu">Baojun Xu</name><affiliation wicri:level="1"><nlm:aff id="af9-ijms-20-02010">Food Science and Technology Program, Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai 519087, Guangdong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Food Science and Technology Program, Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai 519087, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Molecular Sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Rapidly developing resistance against different therapeutics is a major stumbling block in the standardization of therapy. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated signaling has emerged as one of the most highly and extensively studied signal transduction cascade that induces apoptosis in cancer cells. Rapidly emerging cutting-edge research has helped us to develop a better understanding of the signaling machinery involved in inducing apoptotic cell death. However, excitingly, cancer cells develop resistance against TRAIL-induced apoptosis through different modes. Loss of cell surface expression of TRAIL receptors and imbalance of stoichiometric ratios of pro- and anti-apoptotic proteins play instrumental roles in rewiring the machinery of cancer cells to develop resistance against TRAIL-based therapeutics. Natural products have shown excellent potential to restore apoptosis in TRAIL-resistant cancer cell lines and in mice xenografted with TRAIL-resistant cancer cells. Significantly refined information has previously been added and continues to enrich the existing pool of knowledge related to the natural-product-mediated upregulation of death receptors, rebalancing of pro- and anti-apoptotic proteins in different cancers. In this mini review, we will set spotlight on the most recently published high-impact research related to underlying mechanisms of TRAIL resistance and how these deregulations can be targeted by natural products to restore TRAIL-mediated apoptosis in different cancers.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Maman, S" uniqKey="Maman S">S. Maman</name></author><author><name sortKey="Witz, I P" uniqKey="Witz I">I.P. Witz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sud, A" uniqKey="Sud A">A. Sud</name></author><author><name sortKey="Kinnersley, B" uniqKey="Kinnersley B">B. 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Akao</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Pakistan</li><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Ahmad, Aamir" sort="Ahmad, Aamir" uniqKey="Ahmad A" first="Aamir" last="Ahmad">Aamir Ahmad</name><name sortKey="Attar, Rukset" sort="Attar, Rukset" uniqKey="Attar R" first="Rukset" last="Attar">Rukset Attar</name><name sortKey="Farooqi, Ammad Ahmad" sort="Farooqi, Ammad Ahmad" uniqKey="Farooqi A" first="Ammad Ahmad" last="Farooqi">Ammad Ahmad Farooqi</name><name sortKey="Nisa, Mehr Un" sort="Nisa, Mehr Un" uniqKey="Nisa M" first="Mehr-Un" last="Nisa">Mehr-Un Nisa</name><name sortKey="Sabitaliyevich, Uteuliyev Yerzhan" sort="Sabitaliyevich, Uteuliyev Yerzhan" uniqKey="Sabitaliyevich U" first="Uteuliyev Yerzhan" last="Sabitaliyevich">Uteuliyev Yerzhan Sabitaliyevich</name><name sortKey="Shahwar, Durray" sort="Shahwar, Durray" uniqKey="Shahwar D" first="Durray" last="Shahwar">Durray Shahwar</name><name sortKey="Todorovska, Milica" sort="Todorovska, Milica" uniqKey="Todorovska M" first="Milica" last="Todorovska">Milica Todorovska</name></noCountry><country name="Pakistan"><noRegion><name sortKey="Iqbal, Muhammad Javed" sort="Iqbal, Muhammad Javed" uniqKey="Iqbal M" first="Muhammad Javed" last="Iqbal">Muhammad Javed Iqbal</name></noRegion></country><country name="République populaire de Chine"><noRegion><name sortKey="Xu, Baojun" sort="Xu, Baojun" uniqKey="Xu B" first="Baojun" last="Xu">Baojun Xu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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